The biological utilization of glycine for the synthesis of the protoporphyrin of hemoglobin.
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منابع مشابه
Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis.
The inhibition of delta-aminolevulinic acid (ALA) synthase activity by heme is commonly thought to regulate the overall rate of heme synthesis in erythroid cells. However, since heme inhibits erythroid cell uptake of iron from transferrin, we have tested the hypothesis that in reticulocytes heme regulates its own synthesis by controlling the cellular acquisition of iron from transferrin rather ...
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Riboflavin and protoporphyrin IX are two molecules that participate in oxidation and reduction reactions in the living cell. Changing some functional groups of riboflavin and protoporphyrin IX can provide compounds with self-assembled monolayer properties with wide applications in designing the molecular electronic devices. In this study, the amphiphilic structure of riboflavin and protopor...
متن کاملThe utilization of glycine in the biosynthesis of hemoglobin.
Isotopic studies have demonstrated that glycine is used in the biosynthesis of hemoglobin. Glycine has been tagged in one of three ways: (a) with N’” in the amino group (l-3), (b) with Cl4 in the a-methylene carbon position (4), and (c) with Cl4 in the carboxyl group (5). When any of these three forms of glycine is fed to animals, the isotope is incorporated into hemoglobin, but interesting dif...
متن کاملHeme synthesis and red blood cell dynamics in normal humans and in subjects with polycythemia vera, sickle-cell anemia, and pernicious anemia.
Glycine is known to be specifically utilized for the biologic synthesis of the protoporphyrin of hemoglobin (1). The administration of N15labeled glycine results in the production of red blood cells containing labeled heme. After its formation, the heme as a constituent of hemoglobin remains in the cell until the cell disintegrates. Following the destruction of the red blood cell, little of the...
متن کاملSynthesis of 2-Amino-4hydroxy-1H-Pyrrole-3-Carbonitrile from Glycine Under Microwave Irradiation
Reaction of Glycin with Malononitrile afforded respective Pyrrole. Pyrrole is one of the heterocyclic compounds with very important biological activities. Heterocycles are extremely important because of their wide range of applications that goes from their use as pharmaceuticals and agrochemicals to dyestuffs and additives. In this view, it was proposed to synthesize pyrrole-3-carbonitrile deri...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 166 2 شماره
صفحات -
تاریخ انتشار 1946